ナマケモノの毛皮に抗生物質生産菌か　耐性菌問題に光　コスタリカ

【カウイータＡＦＰ＝時事】ナマケモノの毛皮に抗生物質生産菌が潜んでいる可能性があると、中米コスタリカの研究チームが発表した。近年深刻化している抗生物質が効かない「スーパー耐性菌」の問題に光をもたらすかもしれないと、研究者らは期待を寄せている。研究論文が学術誌エンバイロメンタル・マイクロバイオロジーに掲載された。（写真はナマケモノ。コスタリカの保護区で〈資料写真〉。）
　高温多湿なカリブ海沿岸のジャングルの樹冠に生息するナマケモノは、のんびりとしたコスタリカのシンボルであり、主要な観光資源でもある。
　ナマケモノの皮膚上では虫や藻類、真菌や細菌など微生物の活動が活発で、その一部には疾病リスクもあるが、だが専門家らは、ナマケモノは驚くほど感染症に耐性があると指摘する。
　コスタリカ大学のマックス・チャバリア氏のチームは、コスタリカに生息するフタユビナマケモノとミユビナマケモノの複数の個体から毛皮のサンプルを採取。感染制御システムについて調査した結果、「潜在的病原細菌の増殖を制御できる」抗生物質生産菌が存在する可能性が明らかになった。
　この研究を２０２０年に始めたチャバリア氏は、ナマケモノの毛皮の微生物相の制御に関与している細菌の「候補」としてすでに約２０種を特定している。だが同氏は、それらがヒトに有用かどうか結論を出すまでの道のりは長いと述べた。
　世界保健機関（ＷＨＯ）は、耐性菌感染による世界の年間死者数は２０５０年に１０００万人を超えると推定している。【翻訳編集ＡＦＰＢＢＮｅｗｓ】
〔ＡＦＰ＝時事〕（2023/05/02-16:53）

The fur of Costa Rican sloths appears to harbor antibiotic-producing bacteria that scientists hope may hold a solution to the growing problem of superbugs resistant to humanity's dwindling arsenal of drugs.
Sloth fur, research has found, hosts bustling communities of insects, algae, fungi and bacteria, among other microbes, some of which could pose disease risk.
Yet, experts say, the famously slow-moving mammals appear to be surprisingly infection-proof.
If you look at the sloth's fur, you see movement: you see moths, you see different types of insects... a very extensive habitat, Max Chavarria, a researcher at the University of Costa Rica, told AFP.
Obviously when there is co-existence of many types of organisms, there must also be systems that control them, he said.
Chavarria and a team took fur samples from Costa Rican two- and three-toed sloths to examine what that control system could be.
They found the possible existence of antibiotic-producing bacteria that makes it possible to control the proliferation of potentially pathogenic bacteria... or inhibit other competitors such as fungi, according to a study published in the journal Environmental Microbiology.
- 'No infection' -
The sloth is a national symbol in laid back Costa Rica, and a major tourist attraction for the Central American country.
Both the two-toed (Choloepus Hoffmanni) and three-toed (Bradypus variegatus) sloth species have seen their populations decline, according to the International Union for the Conservation of Nature's Red List of Threatened Species.
They live in the canopies of trees in the jungle on the Caribbean coast, where the climate is hot and humid.
American Judy Avey runs a sanctuary in the balmy jungle to care for sloths injured after coming into contact with humans or other animals.
She treats and rehabilitates the creatures with a view to releasing them back into the wild.
We've never received a sloth that has been sick, that has a disease or has an illness, she told AFP.
We've received sloths that had been burned by power lines and their entire arm is just destroyed... and there's no infection.
I think maybe in the 30 years (we've been open), we've seen five animals that have come in with an infected injury. So that tells us there's something going on in their... bodily ecosystem.
Avey, who established the sanctuary with her late Costa Rican husband, Luis Arroyo, had never even heard of a sloth back home in Alaska.
Since receiving her first sloth, whom she named Buttercup, in 1992, she has cared for around 1,000 animals.
- Penicillin inspiration -
Researcher Chavarria took fur samples taken from sloths at the sanctuary to examine in his laboratory.
He began his research in 2020, and has already pinpointed 20 candidate microorganisms waiting to be named.
But he said there is a long road ahead in determining whether the sloth compounds could be useful to humans.
Before thinking about an application in human health, it's important to first understand... what type of molecules are involved, said Chavarria.
An example of this is penicillin, discovered in 1928 by British scientist Alexander Fleming, who discovered that a fungal contamination of a laboratory culture appeared to kill a disease-causing bacteria.
His discovery of the world's first bacteria-killer, or antibiotic, earned him the 1945 Nobel Prize in medicine.
However, microbial resistance to antibiotics has been a growing problem, meaning some medicines no longer work to fight the infections they were designed to treat.
Antimicrobial resistance is a natural phenomenon, but the overuse and misuse of antibiotics in humans, animals and plants has made the problem worse.
The World Health Organization estimates that by 2050, resistance to antibiotics could cause 10 million deaths a year.
Projects like ours can contribute to finding... new molecules that can, in the medium or long term, be used in this battle against antibiotic resistance, said Chavarria.