唾液検査で脳振とう診断、英大学が「画期的」な研究発表　ラグビー

【ロンドンＡＦＰ＝時事】15人制ラグビーで、脳振とう対応のスピードと正確性を高める可能性を秘めた「画期的」な唾液検査があるという研究報告が、23日に発表された。（写真は資料写真）
　ラグビーをはじめとするコンタクトスポーツでは、一流選手たちのプレーの激しさに対する懸念が増す中で、脳振とうが大きな問題になっている。
　英イングランドでは２２日、若年性認知症と診断された元代表のダン・スカボロー氏が、２００３年のＷ杯優勝メンバーであるスティーブ・トンプソン氏らが起こしている集団訴訟に参加した。トンプソン氏らは、ワールドラグビーをはじめとする統括団体を相手取り、団体は脳振とうのリスクから選手を守る努力を怠ったと訴えている。
　アメリカンフットボールでは、元選手が同様の訴訟を起こして協会が莫大（ばくだい）な補償金の支払いを命じられた事例があり、同様の事態を恐れる複数のスポーツで、脳振とうへの対応が課題になっている。
　その中で、今回英国の専門誌に掲載された「ＳＣＲＵＭ（１５人制ラグビーにおけるｍｉＲＮＡを用いた脳振とうの研究）」の調査結果を示した論文では、史上初めて、唾液中のバイオマーカーと呼ばれる特定の分子を分析することで、選手の脳振とうの有無を判断できる可能性が示された。
　重要なのは、この検査では衝撃の直後に出る影響と、数日後に表れる影響の両方が分かる点で、プロのようにフィールド脇で医療スタッフによる本格的な治療が受けられないことが多いアマチュアラグビーでも、助けになる可能性がある。
　今回の論文は、バーミンガム大学が３年にわたって実施した調査プログラムの結果をまとめたもので、イングランドラグビー協会（ＲＦＵ）も関わっている。調査では、プレミアシップとチャンピオンシップという、イングランドの１部と２部の男子プロ選手１０２８人を対象にバイオマーカー分析を実施し、脳振とうを９６パーセントの精度で診断できることが分かった。
　調査結果は次週行われるワールドラグビーのシンポジウムでも紹介される予定で、別のトップレベルの大会二つでも、唾液検査が試験的に実施される見通しだという。【翻訳編集ＡＦＰＢＢＮｅｗｓ】
〔ＡＦＰ＝時事〕（2021/03/25-11:32）

A new game-changing saliva test could provide quicker and more accurate treatment of concussion in rugby union, according to a study published on Tuesday.
Concussion has become a major concern within the contact sport as fears grow about the impact of its increasing ferocity on elite-level players.
Former England international Dan Scarbrough, diagnosed with early onset dementia, said Monday he had joined a case involving 2003 World Cup-winner Steve Thompson.
They allege several rugby authorities, including World Rugby, the sport's global governing body, failed to protect players from the risks of concussion.
It is an issue for several sports who fear costly litigation similar to that which has engulfed American football.
The gridiron game has seen multi-million dollar payouts made to former players who, unlike their rugby counterparts, were wearing helmets that protected their skull but still suffered severe brain injuries.
However, the SCRUM (Study of Concussion in Rugby Union through MicroRNAs) paper published in the British Journal of Sports Medicine says that, for the first time, specific salivary molecules known as biomarkers can indicate if a player has been concussed.
Significantly, the saliva test shows both the immediate impact of any trauma and its effect several days later -- something which may also benefit amateur rugby, where it is rare to have the same extensive touchline medical support as in the professional game.
Tuesday's paper follows a three-year programme conducted by the University of Birmingham in central England and involving England's governing Rugby Football Union.
Biomarker analysis carried out on 1,028 professional men's players in England's top two leagues -- the Premiership and Championship --- found the test to be 96 percent accurate in diagnosing concussion.
What's really exciting is we have found a very accurate way of identifying brain trauma and in saliva, which is non-invasive, said Professor Antonio Belli of the University of Birmingham, one of the study's authors.
The next stage will be to make it faster and portable and instantly available to the doctor on the bench, but we are not there yet.
The findings will be shared at next week's World Rugby welfare symposium, which is expected to designate two more elite competitions for further trials.
- 'In-game test ideal' -
Biotechnology company Marker Diagnostics is trying to convert the research into an over-the-counter test for elite male athletes.
Being able to diagnose with an objective test really changes the game in terms of who you assess, and who reports symptoms, said Dr Patrick O'Halloran of Marker.
A professional player suspected of being concussed during a game is subjected to World Rugby's Head Injury Assessment (HIA) procedure.
They are removed from the field and, after a series of checks, a doctor decides whether a player can return or is permanently excluded from the match before further post-game assessment takes place.
Within the elite professional game, men's and women's, it would be ideal to have an in-game test, said study co-author Dr Simon Kemp, the RFU's medical services director.
This test needs to be part of an HIA framework.
The fact the HIA, however, can allow a player taken out of a game to return to action six days later -- previously a concussed rugby player was stood down for a mandatory three weeks -- has proved highly controversial.
The change prompted Dr Barry O'Driscoll, a cousin of Irish rugby great Brian O'Driscoll and himself a former Ireland international, to resign as World Rugby's medical adviser in 2012.
But Dr O'Driscoll, speaking at a conference on Tuesday before the SCRUM paper was published, said: There are blood tests now and saliva tests, which are in their infancy but will provide us with quite a lot of information as to how concussion is going on.
Meanwhile, Belli said further research was needed to see if female players had the same saliva markers, as most concussion studies show differences between men and women.
The death of former England footballer Jeff Astle in 2002 was determined by a coroner to result from a neurodegenerative condition caused by repeated heading of a ball.
Belli said the research could aid football, amid ongoing talks with England's elite Premier League to expand the scope of the study.
He added there were potential applications beyond sport, from road-traffic accidents, to military settings where making diagnoses is tricky.